Loading…
skip to main content
Medication Excretion
Medication Excretion81105
Please enable Javascript

MEDICAL ANIMATION TRANSCRIPT: The body filters drugs from the bloodstream and eliminates them in a multi-step process called medication excretion. The kidneys are the major route for drug elimination. Most drugs exit the body either unchanged or as drug metabolites in urine. Generally, health professionals refer to the ability of the kidneys to filter blood as renal function. Nephrons, the functional and anatomical units of the kidney, filter blood, regulate fluid volume and pH, and control levels of electrolytes in the body. Each nephron contains a renal corpuscle and renal tubule. The renal corpuscle includes the Bowman capsule and glomerulus. And the renal tubule is composed of the proximal tubule, loop of Henle, distal tubule, and collecting duct. Each component plays a role in renal drug excretion, a four-step process that allows the kidneys to filter and eliminate drugs from the body. These steps are: glomerular filtration, passive tubular reabsorption, active tubular secretion, and excretion. Blood flows into the glomerulus via a blood vessel larger in diameter than the vessel draining blood from the glomerulus. This difference in diameter creates the high blood pressure necessary to filter wastes from the blood. The glomerulus functions as a molecular sieve. Waste materials in water pass through the sieve, while most normal proteins and cells are kept in the bloodstream. Glomerular filtration removes low-molecular-weight drugs from the bloodstream. The process of passive reabsorption of water, solutes, and ions begins in the proximal tubule, continues in the Henle loop, and ends in the distal and collecting ducts. Water-soluble drugs stay in the tubule, while unionized and lipid-soluble drugs are primarily reabsorbed across renal tubules. After reabsorption, lipid-soluble drugs travel through the bloodstream to the liver where certain liver enzymes, such as the cytochrome P450 enzyme complex, metabolize them into more water-soluble forms. Here we show an example of this process through the metabolism of pentobarbital. Some drugs are not filtered from the blood via the glomerulus. Instead, special anionic and cationic pumps in the walls of the renal tubule actively transport the drugs from the blood into the tubules and collecting duct. Urine from the collecting ducts travel through the ureters where it is collected and stored in the urinary bladder until elimination from the body. Although the kidneys are the major route for drug elimination, medication excretion can also occur in lactating women through their breast milk, exhalation through the lungs, release into bile, and elimination through saliva and sweat. [music]

ANM10007 04:43

Last Updated: Jul 2nd, 2020

Keywords

Nucleus Medical Media Disclaimer of Medical and Legal Liability

Nucleus Medical Media ("Nucleus") does not dispense medical or legal advice, and the text, illustrations, photographs, animations and other information ("Content") available on this web site is for general information purposes only. As with any medical or legal issue, it is up to you to consult a physician or attorney for professional advice. YOU SHOULD NOT DISREGARD PROFESSIONAL MEDICAL OR LEGAL ADVICE BASED ON CONTENT CONTAINED ON THIS WEB SITE, NOR SHOULD YOU RELY ON THE CONTENT ON THIS WEB SITE IN PLACE OF PROFESSIONAL MEDICAL OR LEGAL ADVICE.

NUCLEUS DISCLAIMS ALL RESPONSIBILITY AND LIABILITY FOR ANY COUNSEL, ADVICE, TREATMENT, DIAGNOSIS OR ANY MEDICAL, LEGAL OR OTHER INFORMATION, SERVICES OR PRODUCTS THAT YOU OBTAIN BASED ON VIEWING THE CONTENT OF THIS SITE. THE INFORMATION ON THIS WEB SITE SHOULD NOT BE CONSIDERED COMPLETE OR SUITABLE FOR ANY PURPOSE WHATSOEVER.

Mature Content Disclaimer: Certain Content on this web site contains graphic depictions or descriptions of medical information, which may be offensive to some viewers. Nucleus, its licensors, and its suppliers disclaim all responsibility for such materials.

close