Factor VIII Deficiency (Acquired Hemophilia)
This stock medical exhibit features a very simplified and easy to understand comparison of normal blood clotting vs. Factor VIII deficiency with inadequate clotting. This exhibit offers an overall understanding of the importance of Factor VIII in the clotting process. The exhibit begins by illustrating the normal clotting mechanism. A series of cut-away views of a normal artery showing blood flowing through the lumen. This blood contains multiple tiny shapes inside it including small fibers representing clotting factors and small bright green dots representing Factor VIII. The first image illustrates normal anatomy with a text label pointing out that normal blood contains a variety of clotting factors. The second image shows a small cut in the vessel wall leading to a small amount of hemorrhage as blood oozes from this wound. At the site of the wound, we'll show an accumulation of other various clotting fibers and the beginnings of the formation of a blood clot within the wound. The final image shows a clot completely sealing the wound and stopping the bleeding. Text labels for these images describe how Factor VIII activates other clotting agents that clump together forming a clot to stop bleeding. Also, a similar series of images is included to illustrate a similar series of events in a patient with Factor VIII deficiency. In the first image the blood is the same but there aren't green dots representing Factor VIII. The second image shows the perforation of the vessel and the initial vessel. The third image illustrates the continued bleeding with no clotting factors accumulating in the wound. The final image shows continued oozing of blood resulting in a large amount of hemorrhage outside the vessel. Labels point out the absence of Factor VIII results in a failure of the activation and accumulation in clotting agents at the site of the wound with no clot formation to stop the bleeding from the damaged vessel.